Gene information
Official symbol IL1B
Official full name interleukin 1 beta
Gene type protein-coding gene
Chromosome2q14.1
Alias symbolIL1F2; IL-1B; IL1-BETA
Gene familyInterleukins
Resources
Entrez Gene 3553
HGNC HGNC:5992
Ensembl ENSG00000125538
Vega OTTHUMG00000131344
UCSC uc002tii.2
GO terms: 338 records
GO Description Category LogP Number of genes Detail
GO:0000165 MAPK cascade GO Biological Processes -7.43732657 14 More
GO:0000323 lytic vacuole GO Cellular Components -7.25784656 30 More
GO:0001659 temperature homeostasis GO Biological Processes -5.81640478 6 More
GO:0001775 cell activation GO Biological Processes -43.3738118 71 More
GO:0001816 cytokine production GO Biological Processes -9.14810130 8 More
GO:0001819 positive regulation of cytokine production GO Biological Processes -44.1872667 64 More
GO:0001933 negative regulation of protein phosphorylation GO Biological Processes -19.8214973 59 More
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0002237 response to molecule of bacterial origin GO Biological Processes -48.4964960 93 More
GO:0002526 acute inflammatory response GO Biological Processes -34.5980034 29 More
GO:0002673 regulation of acute inflammatory response GO Biological Processes -15.6954767 14 More
GO:0002675 positive regulation of acute inflammatory response GO Biological Processes -10.8573789 13 More
GO:0002694 regulation of leukocyte activation GO Biological Processes -32.0887020 60 More
GO:0002696 positive regulation of leukocyte activation GO Biological Processes -27.9249645 47 More
GO:0002697 regulation of immune effector process GO Biological Processes -33.2683521 48 More
GO:0002699 positive regulation of immune effector process GO Biological Processes -18.3926498 29 More
GO:0002700 regulation of production of molecular mediator of immune response GO Biological Processes -19.7615296 26 More
GO:0002702 positive regulation of production of molecular mediator of immune response GO Biological Processes -12.4206918 17 More
GO:0002703 regulation of leukocyte mediated immunity GO Biological Processes -18.0432682 27 More
GO:0002705 positive regulation of leukocyte mediated immunity GO Biological Processes -8.38274670 14 More
GO:0002706 regulation of lymphocyte mediated immunity GO Biological Processes -13.7265777 21 More
GO:0002708 positive regulation of lymphocyte mediated immunity GO Biological Processes -8.31079168 13 More
GO:0002709 regulation of T cell mediated immunity GO Biological Processes -8.74858930 12 More
GO:0002711 positive regulation of T cell mediated immunity GO Biological Processes -6.00483593 8 More
GO:0002718 regulation of cytokine production involved in immune response GO Biological Processes -15.9157324 18 More
GO:0002720 positive regulation of cytokine production involved in immune response GO Biological Processes -8.11676834 10 More
GO:0002724 regulation of T cell cytokine production GO Biological Processes -9.29772341 9 More
GO:0002791 regulation of peptide secretion GO Biological Processes -16.5189310 23 More
GO:0002819 regulation of adaptive immune response GO Biological Processes -16.0189388 24 More
GO:0002821 positive regulation of adaptive immune response GO Biological Processes -12.1298033 16 More
GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -14.6775052 22 More
GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -10.1498702 14 More
GO:0002831 regulation of response to biotic stimulus GO Biological Processes -10.931136 25 More
GO:0002920 regulation of humoral immune response GO Biological Processes -5.73581155 7 More
GO:0002922 positive regulation of humoral immune response GO Biological Processes -6.27426612 6 More
GO:0003012 muscle system process GO Biological Processes -27.3938503 63 More
GO:0005125 cytokine activity GO Molecular Functions -54.7097150 57 More
GO:0005126 cytokine receptor binding GO Molecular Functions -41.4908940 50 More
GO:0005178 integrin binding GO Molecular Functions -20.5409412 26 More
GO:0005764 lysosome GO Cellular Components -7.25784656 30 More
GO:0006022 aminoglycan metabolic process GO Biological Processes -3.10129957 14 More
GO:0006469 negative regulation of protein kinase activity GO Biological Processes -12.6852914 37 More
GO:0006935 chemotaxis GO Biological Processes -33.1726887 55 More
GO:0006953 acute-phase response GO Biological Processes -24.9631834 19 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0007088 regulation of mitotic nuclear division GO Biological Processes -2.33218274 6 More
GO:0007159 leukocyte cell-cell adhesion GO Biological Processes -16.8529519 16 More
GO:0007565 female pregnancy GO Biological Processes -18.4002911 25 More
GO:0007566 embryo implantation GO Biological Processes -9.99023740 10 More
GO:0008285 negative regulation of cell population proliferation GO Biological Processes -53.5569125 147 More
GO:0009410 response to xenobiotic stimulus GO Biological Processes -32.6021211 82 More
GO:0009612 response to mechanical stimulus GO Biological Processes -18.7627330 44 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0009743 response to carbohydrate GO Biological Processes -20.6536066 44 More
GO:0009895 negative regulation of catabolic process GO Biological Processes -10.3621088 43 More
GO:0009896 positive regulation of catabolic process GO Biological Processes -13.5088608 63 More
GO:0010001 glial cell differentiation GO Biological Processes -13.0211768 33 More
GO:0010563 negative regulation of phosphorus metabolic process GO Biological Processes -21.7837721 71 More
GO:0010565 regulation of cellular ketone metabolic process GO Biological Processes -15.3155739 32 More
GO:0010573 vascular endothelial growth factor production GO Biological Processes -10.4763648 6 More
GO:0010575 positive regulation of vascular endothelial growth factor production GO Biological Processes -10.362168 13 More
GO:0010638 positive regulation of organelle organization GO Biological Processes -6.49207636 47 More
GO:0010717 regulation of epithelial to mesenchymal transition GO Biological Processes -12.1292389 25 More
GO:0010718 positive regulation of epithelial to mesenchymal transition GO Biological Processes -11.466629 18 More
GO:0010720 positive regulation of cell development GO Biological Processes -17.713649 52 More
GO:0010721 negative regulation of cell development GO Biological Processes -6.74707916 25 More
GO:0010817 regulation of hormone levels GO Biological Processes -29.5190556 49 More
GO:0010827 regulation of glucose transmembrane transport GO Biological Processes -18.4601079 28 More
GO:0010829 negative regulation of glucose transmembrane transport GO Biological Processes -8.17037988 10 More
GO:0010876 lipid localization GO Biological Processes -20.1994935 34 More
GO:0014002 astrocyte development GO Biological Processes -7.75588867 8 More
GO:0014013 regulation of gliogenesis GO Biological Processes -13.3514185 26 More
GO:0014015 positive regulation of gliogenesis GO Biological Processes -11.0528361 19 More
GO:0014074 response to purine-containing compound GO Biological Processes -9.77915279 26 More
GO:0014805 smooth muscle adaptation GO Biological Processes -7.71159683 4 More
GO:0019216 regulation of lipid metabolic process GO Biological Processes -24.8423986 38 More
GO:0019217 regulation of fatty acid metabolic process GO Biological Processes -12.5607102 15 More
GO:0019221 cytokine-mediated signaling pathway GO Biological Processes -27.5840932 43 More
GO:0019915 lipid storage GO Biological Processes -7.70033953 8 More
GO:0021782 glial cell development GO Biological Processes -9.97103962 23 More
GO:0022407 regulation of cell-cell adhesion GO Biological Processes -32.4337382 53 More
GO:0022409 positive regulation of cell-cell adhesion GO Biological Processes -25.7751074 39 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0030203 glycosaminoglycan metabolic process GO Biological Processes -2.99315950 13 More
GO:0030212 hyaluronan metabolic process GO Biological Processes -2.63397233 5 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0030593 neutrophil chemotaxis GO Biological Processes -16.9449855 18 More
GO:0030595 leukocyte chemotaxis GO Biological Processes -30.6401488 33 More
GO:0030856 regulation of epithelial cell differentiation GO Biological Processes -15.4645914 35 More
GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway GO Biological Processes -2.08003997 3 More
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway GO Biological Processes -2.88014031 3 More
GO:0031056 regulation of histone modification GO Biological Processes -1.94925747 7 More
GO:0031058 positive regulation of histone modification GO Biological Processes -2.48165756 6 More
GO:0031331 positive regulation of cellular catabolic process GO Biological Processes -13.5134767 30 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031349 positive regulation of defense response GO Biological Processes -32.1301903 71 More
GO:0031392 regulation of prostaglandin biosynthetic process GO Biological Processes -5.14025860 6 More
GO:0031400 negative regulation of protein modification process GO Biological Processes -17.0986645 70 More
GO:0031663 lipopolysaccharide-mediated signaling pathway GO Biological Processes -14.0408172 12 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032303 regulation of icosanoid secretion GO Biological Processes -5.74582458 8 More
GO:0032305 positive regulation of icosanoid secretion GO Biological Processes -5.92579036 8 More
GO:0032306 regulation of prostaglandin secretion GO Biological Processes -4.91299256 6 More
GO:0032308 positive regulation of prostaglandin secretion GO Biological Processes -4.91299256 6 More
GO:0032368 regulation of lipid transport GO Biological Processes -34.5766289 54 More
GO:0032370 positive regulation of lipid transport GO Biological Processes -15.5410017 17 More
GO:0032386 regulation of intracellular transport GO Biological Processes -4.43340887 15 More
GO:0032388 positive regulation of intracellular transport GO Biological Processes -2.01592226 7 More
GO:0032496 response to lipopolysaccharide GO Biological Processes -45.257773 87 More
GO:0032642 regulation of chemokine production GO Biological Processes -25.2850711 37 More
GO:0032649 regulation of interferon-gamma production GO Biological Processes -12.4733429 27 More
GO:0032675 regulation of interleukin-6 production GO Biological Processes -28.2553997 51 More
GO:0032677 regulation of interleukin-8 production GO Biological Processes -20.0046302 33 More
GO:0032722 positive regulation of chemokine production GO Biological Processes -22.4503100 21 More
GO:0032729 positive regulation of interferon-gamma production GO Biological Processes -7.58110530 10 More
GO:0032755 positive regulation of interleukin-6 production GO Biological Processes -18.6559032 31 More
GO:0032757 positive regulation of interleukin-8 production GO Biological Processes -14.6396218 15 More
GO:0032768 regulation of monooxygenase activity GO Biological Processes -14.2762890 21 More
GO:0032770 positive regulation of monooxygenase activity GO Biological Processes -9.70418585 13 More
GO:0032872 regulation of stress-activated MAPK cascade GO Biological Processes -11.6818048 20 More
GO:0032874 positive regulation of stress-activated MAPK cascade GO Biological Processes -9.63549885 15 More
GO:0032890 regulation of organic acid transport GO Biological Processes -14.1608908 23 More
GO:0032892 positive regulation of organic acid transport GO Biological Processes -8.61037442 14 More
GO:0032944 regulation of mononuclear cell proliferation GO Biological Processes -24.6915018 34 More
GO:0032946 positive regulation of mononuclear cell proliferation GO Biological Processes -20.2231223 25 More
GO:0033157 regulation of intracellular protein transport GO Biological Processes -4.35957871 12 More
GO:0033673 negative regulation of kinase activity GO Biological Processes -12.5521161 39 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0034114 regulation of heterotypic cell-cell adhesion GO Biological Processes -12.8696023 10 More
GO:0034116 positive regulation of heterotypic cell-cell adhesion GO Biological Processes -9.73495436 7 More
GO:0034762 regulation of transmembrane transport GO Biological Processes -31.7284805 100 More
GO:0034763 negative regulation of transmembrane transport GO Biological Processes -22.14661 42 More
GO:0038034 signal transduction in absence of ligand GO Biological Processes -2.36203981 3 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042063 gliogenesis GO Biological Processes -20.3412228 47 More
GO:0042102 positive regulation of T cell proliferation GO Biological Processes -13.4787271 17 More
GO:0042129 regulation of T cell proliferation GO Biological Processes -18.0871480 25 More
GO:0042176 regulation of protein catabolic process GO Biological Processes -8.45353494 23 More
GO:0042304 regulation of fatty acid biosynthetic process GO Biological Processes -6.97247167 8 More
GO:0042326 negative regulation of phosphorylation GO Biological Processes -20.6187298 64 More
GO:0042330 taxis GO Biological Processes -33.0828571 55 More
GO:0042742 defense response to bacterium GO Biological Processes -25.9215771 41 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO Biological Processes -8.71585030 18 More
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO Biological Processes -8.04470175 15 More
GO:0043269 regulation of ion transport GO Biological Processes -36.9814668 116 More
GO:0043270 positive regulation of ion transport GO Biological Processes -23.5832054 34 More
GO:0043405 regulation of MAP kinase activity GO Biological Processes -18.9267681 42 More
GO:0043406 positive regulation of MAP kinase activity GO Biological Processes -13.8261343 18 More
GO:0043407 negative regulation of MAP kinase activity GO Biological Processes -8.66647370 10 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043409 negative regulation of MAPK cascade GO Biological Processes -13.5471736 35 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043491 protein kinase B signaling GO Biological Processes -12.2973970 11 More
GO:0043500 muscle adaptation GO Biological Processes -8.52594673 12 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0044070 regulation of anion transport GO Biological Processes -12.6410846 24 More
GO:0044703 multi-organism reproductive process GO Biological Processes -20.5752550 28 More
GO:0044706 multi-multicellular organism process GO Biological Processes -20.0155761 28 More
GO:0045428 regulation of nitric oxide biosynthetic process GO Biological Processes -19.2075726 26 More
GO:0045429 positive regulation of nitric oxide biosynthetic process GO Biological Processes -13.6962150 18 More
GO:0045596 negative regulation of cell differentiation GO Biological Processes -26.9785067 101 More
GO:0045601 regulation of endothelial cell differentiation GO Biological Processes -11.5275821 17 More
GO:0045723 positive regulation of fatty acid biosynthetic process GO Biological Processes -5.19191118 5 More
GO:0045732 positive regulation of protein catabolic process GO Biological Processes -6.83749864 15 More
GO:0045765 regulation of angiogenesis GO Biological Processes -63.6171248 109 More
GO:0045766 positive regulation of angiogenesis GO Biological Processes -39.3444092 63 More
GO:0045785 positive regulation of cell adhesion GO Biological Processes -29.6368249 50 More
GO:0045787 positive regulation of cell cycle GO Biological Processes -4.54703082 15 More
GO:0045833 negative regulation of lipid metabolic process GO Biological Processes -7.94928400 20 More
GO:0045834 positive regulation of lipid metabolic process GO Biological Processes -24.1838255 28 More
GO:0045840 positive regulation of mitotic nuclear division GO Biological Processes -3.57424917 5 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0045860 positive regulation of protein kinase activity GO Biological Processes -29.3929160 47 More
GO:0045862 positive regulation of proteolysis GO Biological Processes -17.3242033 33 More
GO:0045923 positive regulation of fatty acid metabolic process GO Biological Processes -10.6446744 10 More
GO:0045936 negative regulation of phosphate metabolic process GO Biological Processes -21.8424865 71 More
GO:0046328 regulation of JNK cascade GO Biological Processes -6.26985667 21 More
GO:0046330 positive regulation of JNK cascade GO Biological Processes -6.26494407 10 More
GO:0046626 regulation of insulin receptor signaling pathway GO Biological Processes -7.79385832 16 More
GO:0046627 negative regulation of insulin receptor signaling pathway GO Biological Processes -4.76875730 9 More
GO:0046683 response to organophosphorus GO Biological Processes -8.57801626 23 More
GO:0046822 regulation of nucleocytoplasmic transport GO Biological Processes -4.16168961 8 More
GO:0046824 positive regulation of nucleocytoplasmic transport GO Biological Processes -4.10947470 6 More
GO:0046883 regulation of hormone secretion GO Biological Processes -20.4338227 29 More
GO:0046888 negative regulation of hormone secretion GO Biological Processes -8.59327523 10 More
GO:0046889 positive regulation of lipid biosynthetic process GO Biological Processes -14.1380112 16 More
GO:0046890 regulation of lipid biosynthetic process GO Biological Processes -16.6841590 23 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048143 astrocyte activation GO Biological Processes -5.69256069 5 More
GO:0048708 astrocyte differentiation GO Biological Processes -6.43952602 8 More
GO:0048871 multicellular organismal homeostasis GO Biological Processes -14.5562171 53 More
GO:0050670 regulation of lymphocyte proliferation GO Biological Processes -22.6006415 32 More
GO:0050671 positive regulation of lymphocyte proliferation GO Biological Processes -19.1485102 24 More
GO:0050708 regulation of protein secretion GO Biological Processes -30.3716714 63 More
GO:0050709 negative regulation of protein secretion GO Biological Processes -12.5236372 21 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050729 positive regulation of inflammatory response GO Biological Processes -38.1621935 57 More
GO:0050764 regulation of phagocytosis GO Biological Processes -16.0793009 29 More
GO:0050766 positive regulation of phagocytosis GO Biological Processes -13.5971167 15 More
GO:0050767 regulation of neurogenesis GO Biological Processes -15.7439029 55 More
GO:0050768 negative regulation of neurogenesis GO Biological Processes -6.01402466 11 More
GO:0050769 positive regulation of neurogenesis GO Biological Processes -12.1167088 37 More
GO:0050778 positive regulation of immune response GO Biological Processes -17.2528761 40 More
GO:0050796 regulation of insulin secretion GO Biological Processes -13.8348879 19 More
GO:0050804 modulation of chemical synaptic transmission GO Biological Processes -15.2260557 60 More
GO:0050805 negative regulation of synaptic transmission GO Biological Processes -5.05172294 12 More
GO:0050830 defense response to Gram-positive bacterium GO Biological Processes -13.1972375 17 More
GO:0050839 cell adhesion molecule binding GO Molecular Functions -14.4506551 68 More
GO:0050863 regulation of T cell activation GO Biological Processes -20.3209154 36 More
GO:0050865 regulation of cell activation GO Biological Processes -40.6877761 71 More
GO:0050867 positive regulation of cell activation GO Biological Processes -31.2431659 51 More
GO:0050870 positive regulation of T cell activation GO Biological Processes -17.6497748 28 More
GO:0050900 leukocyte migration GO Biological Processes -39.9164759 46 More
GO:0050994 regulation of lipid catabolic process GO Biological Processes -9.86212956 11 More
GO:0050995 negative regulation of lipid catabolic process GO Biological Processes -4.91348267 5 More
GO:0050996 positive regulation of lipid catabolic process GO Biological Processes -5.87603013 9 More
GO:0050999 regulation of nitric-oxide synthase activity GO Biological Processes -9.05830591 14 More
GO:0051043 regulation of membrane protein ectodomain proteolysis GO Biological Processes -16.3022563 12 More
GO:0051044 positive regulation of membrane protein ectodomain proteolysis GO Biological Processes -9.19233133 7 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051047 positive regulation of secretion GO Biological Processes -32.2282376 71 More
GO:0051048 negative regulation of secretion GO Biological Processes -20.2278199 42 More
GO:0051051 negative regulation of transport GO Biological Processes -46.8709407 107 More
GO:0051090 regulation of DNA-binding transcription factor activity GO Biological Processes -25.8933515 78 More
GO:0051091 positive regulation of DNA-binding transcription factor activity GO Biological Processes -17.7436786 49 More
GO:0051092 positive regulation of NF-kappaB transcription factor activity GO Biological Processes -14.8614421 21 More
GO:0051129 negative regulation of cellular component organization GO Biological Processes -13.1016989 75 More
GO:0051222 positive regulation of protein transport GO Biological Processes -13.8994291 46 More
GO:0051223 regulation of protein transport GO Biological Processes -25.2801266 81 More
GO:0051224 negative regulation of protein transport GO Biological Processes -11.0190941 26 More
GO:0051235 maintenance of location GO Biological Processes -6.64896142 13 More
GO:0051249 regulation of lymphocyte activation GO Biological Processes -22.6120519 46 More
GO:0051251 positive regulation of lymphocyte activation GO Biological Processes -20.2181987 37 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051302 regulation of cell division GO Biological Processes -3.83250874 20 More
GO:0051341 regulation of oxidoreductase activity GO Biological Processes -18.1249013 32 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0051348 negative regulation of transferase activity GO Biological Processes -13.2006110 43 More
GO:0051353 positive regulation of oxidoreductase activity GO Biological Processes -12.6682372 20 More
GO:0051781 positive regulation of cell division GO Biological Processes -5.46648014 9 More
GO:0051783 regulation of nuclear division GO Biological Processes -1.91099987 6 More
GO:0051785 positive regulation of nuclear division GO Biological Processes -3.17098953 5 More
GO:0051960 regulation of nervous system development GO Biological Processes -17.2202851 64 More
GO:0051961 negative regulation of nervous system development GO Biological Processes -6.75305746 12 More
GO:0051962 positive regulation of nervous system development GO Biological Processes -13.2580156 43 More
GO:0060251 regulation of glial cell proliferation GO Biological Processes -8.90876897 12 More
GO:0060284 regulation of cell development GO Biological Processes -22.9455891 78 More
GO:0060326 cell chemotaxis GO Biological Processes -35.3882493 41 More
GO:0060341 regulation of cellular localization GO Biological Processes -10.5933083 72 More
GO:0060353 regulation of cell adhesion molecule production GO Biological Processes -7.13135320 9 More
GO:0060558 regulation of calcidiol 1-monooxygenase activity GO Biological Processes -8.3287979 5 More
GO:0060559 positive regulation of calcidiol 1-monooxygenase activity GO Biological Processes -5.78189015 3 More
GO:0060627 regulation of vesicle-mediated transport GO Biological Processes -25.1756709 46 More
GO:0061900 glial cell activation GO Biological Processes -13.6981492 12 More
GO:0062012 regulation of small molecule metabolic process GO Biological Processes -26.8746473 69 More
GO:0062013 positive regulation of small molecule metabolic process GO Biological Processes -17.9792910 37 More
GO:0070201 regulation of establishment of protein localization GO Biological Processes -24.4831554 82 More
GO:0070302 regulation of stress-activated protein kinase signaling cascade GO Biological Processes -11.5600448 20 More
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade GO Biological Processes -9.54226030 15 More
GO:0070372 regulation of ERK1 and ERK2 cascade GO Biological Processes -38.4320790 79 More
GO:0070555 response to interleukin-1 GO Biological Processes -18.9736890 36 More
GO:0070663 regulation of leukocyte proliferation GO Biological Processes -26.8242532 37 More
GO:0070665 positive regulation of leukocyte proliferation GO Biological Processes -21.5362473 27 More
GO:0070851 growth factor receptor binding GO Molecular Functions -16.9609899 22 More
GO:0071214 cellular response to abiotic stimulus GO Biological Processes -11.2775864 23 More
GO:0071216 cellular response to biotic stimulus GO Biological Processes -28.1549742 59 More
GO:0071219 cellular response to molecule of bacterial origin GO Biological Processes -28.3848077 56 More
GO:0071222 cellular response to lipopolysaccharide GO Biological Processes -26.0381191 52 More
GO:0071260 cellular response to mechanical stimulus GO Biological Processes -11.7214175 13 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0071347 cellular response to interleukin-1 GO Biological Processes -16.1002741 19 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0071407 cellular response to organic cyclic compound GO Biological Processes -19.6857751 39 More
GO:0071466 cellular response to xenobiotic stimulus GO Biological Processes -9.33788411 28 More
GO:0071496 cellular response to external stimulus GO Biological Processes -17.0078490 52 More
GO:0071621 granulocyte chemotaxis GO Biological Processes -16.4324548 18 More
GO:0071637 regulation of monocyte chemotactic protein-1 production GO Biological Processes -4.00389964 4 More
GO:0071639 positive regulation of monocyte chemotactic protein-1 production GO Biological Processes -3.56180292 5 More
GO:0071900 regulation of protein serine/threonine kinase activity GO Biological Processes -19.5794055 63 More
GO:0071901 negative regulation of protein serine/threonine kinase activity GO Biological Processes -13.7044922 29 More
GO:0071902 positive regulation of protein serine/threonine kinase activity GO Biological Processes -13.5008002 23 More
GO:0080135 regulation of cellular response to stress GO Biological Processes -19.0128542 89 More
GO:0080164 regulation of nitric oxide metabolic process GO Biological Processes -19.7892071 27 More
GO:0090068 positive regulation of cell cycle process GO Biological Processes -2.40180572 9 More
GO:0090087 regulation of peptide transport GO Biological Processes -16.3568662 23 More
GO:0090276 regulation of peptide hormone secretion GO Biological Processes -16.6841590 23 More
GO:0090287 regulation of cellular response to growth factor stimulus GO Biological Processes -21.1381780 60 More
GO:0090316 positive regulation of intracellular protein transport GO Biological Processes -2.57210479 7 More
GO:0097190 apoptotic signaling pathway GO Biological Processes -11.7839485 23 More
GO:0097191 extrinsic apoptotic signaling pathway GO Biological Processes -9.74858067 13 More
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand GO Biological Processes -2.36203981 3 More
GO:0097529 myeloid leukocyte migration GO Biological Processes -25.8454617 28 More
GO:0097530 granulocyte migration GO Biological Processes -19.1764933 21 More
GO:0098609 cell-cell adhesion GO Biological Processes -15.7963965 69 More
GO:0099177 regulation of trans-synaptic signaling GO Biological Processes -15.1793607 60 More
GO:0104004 cellular response to environmental stimulus GO Biological Processes -11.2775864 23 More
GO:0150076 neuroinflammatory response GO Biological Processes -13.2187099 12 More
GO:0150077 regulation of neuroinflammatory response GO Biological Processes -14.4671881 13 More
GO:1900076 regulation of cellular response to insulin stimulus GO Biological Processes -8.81141992 11 More
GO:1900077 negative regulation of cellular response to insulin stimulus GO Biological Processes -5.46127869 10 More
GO:1900744 regulation of p38MAPK cascade GO Biological Processes -6.86981007 8 More
GO:1900745 positive regulation of p38MAPK cascade GO Biological Processes -6.802042 7 More
GO:1901224 positive regulation of NIK/NF-kappaB signaling GO Biological Processes -6.64954322 9 More
GO:1901342 regulation of vasculature development GO Biological Processes -64.8504074 111 More
GO:1901550 regulation of endothelial cell development GO Biological Processes -5.90191637 5 More
GO:1901888 regulation of cell junction assembly GO Biological Processes -8.71146171 30 More
GO:1901889 negative regulation of cell junction assembly GO Biological Processes -5.33337113 9 More
GO:1902532 negative regulation of intracellular signal transduction GO Biological Processes -29.4927428 92 More
GO:1903037 regulation of leukocyte cell-cell adhesion GO Biological Processes -23.2079690 66 More
GO:1903039 positive regulation of leukocyte cell-cell adhesion GO Biological Processes -20.7355312 32 More
GO:1903140 regulation of establishment of endothelial barrier GO Biological Processes -5.90191637 5 More
GO:1903510 mucopolysaccharide metabolic process GO Biological Processes -2.64314024 10 More
GO:1903530 regulation of secretion by cell GO Biological Processes -45.6472055 114 More
GO:1903531 negative regulation of secretion by cell GO Biological Processes -17.4034654 36 More
GO:1903532 positive regulation of secretion by cell GO Biological Processes -27.9542102 63 More
GO:1903596 regulation of gap junction assembly GO Biological Processes -11.9605730 7 More
GO:1903793 positive regulation of anion transport GO Biological Processes -7.11509809 13 More
GO:1903828 negative regulation of protein localization GO Biological Processes -8.86943289 30 More
GO:1903829 positive regulation of protein localization GO Biological Processes -12.9651258 57 More
GO:1904018 positive regulation of vasculature development GO Biological Processes -39.3444092 63 More
GO:1904407 positive regulation of nitric oxide metabolic process GO Biological Processes -14.4967625 19 More
GO:1904950 negative regulation of establishment of protein localization GO Biological Processes -11.4813166 27 More
GO:1904951 positive regulation of establishment of protein localization GO Biological Processes -13.0308630 46 More
GO:1905952 regulation of lipid localization GO Biological Processes -40.6150331 64 More
GO:1905954 positive regulation of lipid localization GO Biological Processes -22.7388039 24 More
GO:1990266 neutrophil migration GO Biological Processes -18.6358512 20 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
GO:2000191 regulation of fatty acid transport GO Biological Processes -10.7141263 14 More
GO:2000193 positive regulation of fatty acid transport GO Biological Processes -7.51681508 10 More
GO:2001233 regulation of apoptotic signaling pathway GO Biological Processes -35.8481080 51 More
GO:2001234 negative regulation of apoptotic signaling pathway GO Biological Processes -32.1748782 40 More
GO:2001236 regulation of extrinsic apoptotic signaling pathway GO Biological Processes -20.7647111 26 More
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway GO Biological Processes -19.1764933 21 More
GO:2001279 regulation of unsaturated fatty acid biosynthetic process GO Biological Processes -4.70690316 6 More
KEGG pathways: 41 records
KEGG Description Category LogP Number of genes Detail
hsa04010 MAPK signaling pathway KEGG Pathway -13.6331973 26 More
hsa04060 Cytokine-cytokine receptor interaction KEGG Pathway -61.0014447 66 More
hsa04064 NF-kappa B signaling pathway KEGG Pathway -10.0294934 14 More
hsa04217 Necroptosis KEGG Pathway -8.49909048 15 More
hsa04380 Osteoclast differentiation KEGG Pathway -7.05199617 21 More
hsa04620 Toll-like receptor signaling pathway KEGG Pathway -11.1460554 15 More
hsa04621 NOD-like receptor signaling pathway KEGG Pathway -7.63493695 15 More
hsa04625 C-type lectin receptor signaling pathway KEGG Pathway -5.36927089 9 More
hsa04640 Hematopoietic cell lineage KEGG Pathway -11.4657972 15 More
hsa04657 IL-17 signaling pathway KEGG Pathway -16.8039621 19 More
hsa04659 Th17 cell differentiation KEGG Pathway -9.80516906 14 More
hsa04668 TNF signaling pathway KEGG Pathway -16.5384917 20 More
hsa04750 Inflammatory mediator regulation of TRP channels KEGG Pathway -4.64858532 8 More
hsa04932 Non-alcoholic fatty liver disease KEGG Pathway -11.2628136 17 More
hsa04933 AGE-RAGE signaling pathway in diabetic complications KEGG Pathway -25.8646207 26 More
hsa04936 Alcoholic liver disease KEGG Pathway -13.3477535 19 More
hsa04940 Type I diabetes mellitus KEGG Pathway -8.40921139 9 More
hsa05010 Alzheimer disease KEGG Pathway -5.39034067 17 More
hsa05020 Prion disease KEGG Pathway -2.47073365 10 More
hsa05022 Pathways of neurodegeneration - multiple diseases KEGG Pathway -4.18311884 18 More
hsa05130 Pathogenic Escherichia coli infection KEGG Pathway -9.84822677 18 More
hsa05131 Shigellosis KEGG Pathway -5.26807538 14 More
hsa05133 Pertussis KEGG Pathway -13.2270528 15 More
hsa05134 Legionellosis KEGG Pathway -13.8022551 14 More
hsa05135 Yersinia infection KEGG Pathway -7.02427022 12 More
hsa05140 Leishmaniasis KEGG Pathway -12.4439861 14 More
hsa05142 Chagas disease KEGG Pathway -21.3868632 23 More
hsa05143 African trypanosomiasis KEGG Pathway -18.5080428 15 More
hsa05144 Malaria KEGG Pathway -31.5561809 24 More
hsa05146 Amoebiasis KEGG Pathway -14.8474637 18 More
hsa05152 Tuberculosis KEGG Pathway -14.5221547 22 More
hsa05162 Measles KEGG Pathway -4.80674483 10 More
hsa05163 Human cytomegalovirus infection KEGG Pathway -9.77103740 19 More
hsa05164 Influenza A KEGG Pathway -16.0885267 23 More
hsa05168 Herpes simplex virus 1 infection KEGG Pathway -3.99478875 17 More
hsa05171 Coronavirus disease - COVID-19 KEGG Pathway -24.8179886 34 More
hsa05321 Inflammatory bowel disease KEGG Pathway -16.3800424 16 More
hsa05323 Rheumatoid arthritis KEGG Pathway -22.3868189 23 More
hsa05332 Graft-versus-host disease KEGG Pathway -5.01134628 6 More
hsa05417 Lipid and atherosclerosis KEGG Pathway -33.3876857 40 More
hsa05418 Fluid shear stress and atherosclerosis KEGG Pathway -23.1665561 27 More
Drug-Gene interaction
view
Related drugs: 37 records
Drug name Interaction type Source PMID View
acitretin NCI 29545761431212 view
alteplase NCI 8615653 view
aspirin PharmGKB 19448967 view
canakinumab inhibitorbinderantibody MyCancerGenomeTdgClinicalTrialChemblInteractionsTENDTTD 19169963 view
cefaclor NCI 3260587 view
celastrol TTD view
clodronic acid PharmGKB 16257277 view
diacerein TdgClinicalTrialTTD view
echinacea, unspecified NCI 8951617 view
erythromycin NCI 2534682 view
gevokizumab TdgClinicalTrialChemblInteractions view
glucosamine TTD view
hydrocortisone NCI 2162889 view
hydroquinone NCI 7589278 view
ibudilast TTD view
infliximab PharmGKB 22960943 view
lansoprazole NCIPharmGKB 168153162105446414638340 view
lithium NCI 9342951 view
mafosfamide NCI 3497116 view
melatonin NCI 8077674 view
morphine PharmGKB 27649267 view
nicardipine NCI 1888883 view
ofloxacin NCI 3260587 view
omeprazole PharmGKB 168153162105446414638340 view
pentamidine NCI 8370344 view
pentoxifylline NCI 8048000 view
pravastatin PharmGKB 14515062 view
rabeprazole PharmGKB 168153162105446414638340 view
raloxifene NCI 12773123 view
resveratrol NCI 16389574 view
rilonacept binderinhibitor ChemblInteractionsTTD 2331901923553601 view
risedronic acid PharmGKB 16257277 view
thyroglobulin NCI 2788696 view
tiludronic acid PharmGKB 16257277 view
tt-301 TTD 22131899 view
ustekinumab PharmGKB 28696418 view
verapamil NCI 2686646 view
Related studies: 18 records
Molecular factor Omics type Application Objective MI type Reference
NM_000576.3:c.315C>T genomics myocardial infarction[diagnosis] myocardial infarction Daraei A et al. Genet Test Mol Biomarkers. 2017
NM_000576.3:c.[-3737C>T;-1468G>C;-511C>T] genomics myocardial infarction[diagnosis] myocardial infarction Latella MC et al. Immunol Invest. 2009
interleukin-1 beta proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Balbay Y et al. Angiology. 2001
interleukin-1 beta proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Tabata N et al. PLoS One. 2016
interleukin-1 beta proteomics death[prognosis (bad)] acute ST elevation myocardial infarction Silvain J et al. J Am Coll Cardiol. 2020
interleukin-1 beta proteomics death[prognosis (bad)] acute ST elevation myocardial infarction Silvain J et al. J Am Coll Cardiol. 2020
interleukin-1 beta proteomics major adverse cardiovascular events[prognosis (bad)] acute ST elevation myocardial infarction Silvain J et al. J Am Coll Cardiol. 2020
interleukin-1 beta proteomics cardiovascular death[prognosis (bad)] acute ST elevation myocardial infarction Silvain J et al. J Am Coll Cardiol. 2020
interleukin-1 beta proteomics major adverse cardiovascular events[prognosis (bad)] acute ST elevation myocardial infarction Silvain J et al. J Am Coll Cardiol. 2020
interleukin-1 beta proteomics cardiovascular death[prognosis (bad)] acute ST elevation myocardial infarction Silvain J et al. J Am Coll Cardiol. 2020
NM_000576.3:c.-511C>T genomics myocardial infarction[diagnosis] myocardial infarction Iacoviello L et al. Arterioscler Thromb Vasc Biol. 2005
NC_000002.12:g.112833698A>G genomics myocardial infarction[diagnosis] myocardial infarction Bis JC et al. Atherosclerosis. 2008
NC_000002.12:g.112835941G>A genomics myocardial infarction[diagnosis] myocardial infarction Bis JC et al. Atherosclerosis. 2008
NM_000576.3:c.-1468G>C genomics myocardial infarction[diagnosis] myocardial infarction Zee RY et al. Atherosclerosis. 2008
NM_000576.3:c.-3737C>T genomics myocardial infarction[diagnosis] myocardial infarction Latella MC et al. Immunol Invest. 2009
NM_000576.3:c.-511C>T genomics myocardial infarction[diagnosis] myocardial infarction Latella MC et al. Immunol Invest. 2009
NM_000576.3:c.-511C>T genomics interleukin-1 beta[other] myocardial infarction Yang B et al. Int J Clin Exp Pathol. 2015
NM_000576.3:c.-511C>T genomics myocardial infarction[diagnosis] myocardial infarction Chen L et al. Exp Ther Med. 2018
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